Introduction and Goals - Mouse Mutations Causing Eye and Vision Defects
The aim of this screen is to provide murine models of human ocular diseases where none currently exist. A primary screen will be performed to examine mice for heritable ocular diseases using high-throughput morphologic examinations including dysmorphology surveys, biomicroscopy, and indirect ophthalmoscopy.
In addition, a smaller cohort of 1,400 mice for heritable functional deficits will be screened using electroretinography (ERG) (e.g. nonmorphological rod and cone disorders). These mice will also be reexamined with morphologic surveys and ERG at one year for mid- to late-onset disease.
To further classify heritable mutants of interest, we will then perform secondary screens, including ERG, fluorescein angiography or intraocular pressure measurements, where applicable, and histological analysis.
