STRAIN INFORMATION |
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Family Identifier |
NMF371 | |
Synonym(s) |
Myo7ash1-11J; C57BL/6J-Myo7ash1-11J/J; Myo7ash1-11J; JR#5468 | |
Synopsis |
Circling (bi-directional), head tilt and head tossing behavior; the mutants are deaf. | |
Gene Symbol |
Myo7a (View MGI Record) | |
Gene |
myosin VIIa | |
Allele Symbol |
Myo7anmf371 (View MGI Record) | |
Allele |
neuroscience mutagenesis facility371 | |
Abnormal Assay(s) |
Assay: Auditory brain stem response (ABR) Domain(s): Auditory/Vestibular Assay: Overt movement/posture Domain(s): Visible Mutants |
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Phenotype Description |
The mutants were identified through head tilt, body leaning and bi-directional circling behavior at wean (average onset at 3.5 +/- 0.6 weeks of age; n=31); they also show head tossing behavior. ABR testing showed the mutants to be deaf at all frequencies (8, 16, 32KHz) tested. Because of phenotypic and genotypic similarities to mutants of Myo7a, complementation tests were performed with B6.Cg-Myo7ash1-8J/J (JR#3184); the results of two heterozygous by homozygous matings (5 affected in a total of 24 progeny) suggest that nmf371 represents an allele of Myo7a. (View video) | |
Pathology Report |
Serial sections of the ears of two mutants (160 days of age) revealed a virtual absence of organ of corti, spiral ganglion cells, hair cells or normal otoconia; whole ear exam also showed defective otoconia. Standard pathology work-up revealed no further abnormalities. | |
| HERITABILITY AND MAPPING INFORMATION |
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Background Strain |
C57BL/6J | |
Heritability Mode |
Recessive | |
Heritability Status |
Proven; 3 different heterozygote x heterozygote matings produced 6 mutants in a total of 22 progeny; 1 homozygote x heterozygote mating produced 9 mutants in a total of 15 progeny. | |
Chromosome |
7 | |
Molecular Interval |
see Myo7a | |
Map |
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| STATUS INFORMATION |
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Mutant Status |
Cryopreserved Embryos | |
Comments |
(8) NMF371 have been requested by and distributed to 2 investigator. | |
Contact e-Mail Address |
nmf-mice@jax.org | |