STRAIN INFORMATION |
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Family Identifier |
NMF329 | |
Synonym(s) |
C57BL/6J-nmf329/J; JR#5255 | |
Synopsis |
The mutants are deaf. | |
Gene Symbol |
nmf329 (View MGI Record) | |
Gene |
neuroscience mutagenesis facility329 | |
Allele Symbol |
nmf329 (View MGI Record) | |
Allele |
neuroscience mutagenesis facility329 | |
Abnormal Assay(s) |
Assay: Acoustic startle response (ASR) Domain(s): Auditory/Vestibular Assay: Auditory brain stem response (ABR) Domain(s): Auditory/Vestibular |
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Phenotype Description |
Routine examination for auditory function at 4-5 weeks of age revealed the mutants to be deaf. Acoustic startle response and Auditory brain stem recordings yielded no response at every frequency and intensity tested (click, 8, 16, 32 Hz at 30-90 dB). Mutants of either gender have been produced and the colony is maintained through homozygous breeding. | |
Pathology Report |
Standard pathology work-up on two mutants (46 or 80 days of age) showed no abnormalities. Serial sections of the ears of the younger mutant showed some slight loss of hair cells in the left ear; whole-mount ear exam performed on the older mutant showed the presence of otoconia and no abnormalities. | |
| HERITABILITY AND MAPPING INFORMATION |
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Background Strain |
C57BL/6J | |
Heritability Mode |
Recessive | |
Heritability Status |
Proven; 2 heterozygote x heterozygote matings resulted in 6 deaf mice in a total of 28 progeny; 1 homozygous x heterozygous mating resulted in 5 deaf mice in a total of 12 progeny. | |
Chromosome |
17 | |
Molecular Interval |
D17Mit113 - 4.5 cM - (D17Mit197, nmf329) - 9.7 cM - D17Mit175; linkage: D17Mit197-LOD=9.67; D17Mit113-LOD=10.55 | |
Map |
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| STATUS INFORMATION |
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Mutant Status |
Cryopreserved Embryos | |
Comments |
(11) NMF329 have been requested by and distributed to 2 investigators. | |
Contact e-Mail Address |
nmf-mice@jax.org | |