Family Identifier |
NMF250 |
Synonym(s) |
Nox3nmf250; C57BL/6J-Nox3het-4J/J; C57BL/6J-nmf250/J; JR#5014 |
Synopsis |
The mutants show head and body tilt at 4 weeks of age. |
Gene Symbol |
Nox3 (View MGI Record) |
Gene |
NADPH oxidase 3 |
Allele Symbol |
Nox3nmf250 (View MGI Record) |
Allele |
neuroscience mutagenesis facility250 |
Abnormal Assay(s) |
Assay: Overt movement/posture
Domain(s): Visible Mutants
; Auditory/Vestibular
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Phenotype Description |
These mutants were detected through routine inspections for overt abnormal behavior and the onset of head- and body tilt has been determined to be at 4 weeks of age (+/- 0.3 weeks); occasional circling behavior has also been observed. Results of Auditory brainstem recordings (n=2) were normal. Male or female mutants have been produced and the colony can usually be maintained through homozygous matings. Complementation analysis, i.e. matings between heterozygous nmf250 (female) and homozygous Nox3 mice (male, JR#002557, B6Ei.GL-Nox3het/J) resulted in 5 mutants in a total of 7 progeny, demonstrating that nmf250 represents an allele of Nox3.
(View video)
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Pathology Report |
Standard pathology work-up on two mutants (43 or 112 days of age) revealed no abnormalities. Serial sections of the ears of the older mouse showed a lack of otoconia in the ear, which was confirmed by examination of ear whole mounts of two other mutants. No other abnormalities were observed.
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HERITABILITY AND MAPPING INFORMATION
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Background Strain |
C57BL/6J |
Heritability Mode |
Recessive |
Heritability Status |
Proven; 2 heterozygote x heterozygote matings resulted in 6 affected mice in a total of 22 progeny. |
Chromosome |
17 |
Map
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STATUS INFORMATION
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Mutant Status |
Cryopreserved Embryos
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Comments |
(16) NMF250 have been requested by and distributed to 3 investigators. |
Contact e-Mail Address |
nmf-mice@jax.org |