Family Identifier |
NMF161 |
Synonym(s) |
C57BL/6J-nmf161/J; JR#4816 |
Synopsis |
Intermittent hind- and front limb spasms. |
Gene Symbol |
nmf161 (View MGI Record) |
Gene |
neuroscience mutagenesis facility161 |
Allele Symbol |
nmf161 (View MGI Record) |
Allele |
neuroscience mutagenesis facility161 |
Abnormal Assay(s) |
Assay: Overt movement/posture
Domain(s): Visible Mutants
; Movement/Neuromuscular Function
|
Phenotype Description |
The hind- and front limbs of these mutants exhibit spasms intermittently, i.e. paws or the whole front limb will be contracted, or a hind leg will be briefly stretched to the side or backward while the animal moves around; these episodes are usually very brief, and can be observed at 4 weeks of age (average onset 4.6 +/- 0.8 weeks of age; n=15). The mice also rise frequently on their hind limbs. Mutants breed, and the colony is maintained through mutant x heterozygote or heterozygote x heterozygote breedings.
(View video)
|
Pathology Report |
Standard pathology work-up on two mutants (37 or 258 days of age) showed a lack of myelin in the cortical spinal tract. Bodian staining was performed on spinal cord tissue of the older mouse and revealed no other abnormalities. |
HERITABILITY AND MAPPING INFORMATION
|
Background Strain |
C57BL/6J |
Heritability Mode |
Recessive |
Heritability Status |
Proven; 3 heterozygous x heterozygous matings produced 4 mutants in a total of 18 progeny. |
STATUS INFORMATION
|
Mutant Status |
Cryopreserved Embryos
|
Comments |
Please note: While this mutation is available, it has not yet been chromosomally mapped - an important part of determining whether it is allelic with a previously characterized mutation. (6) NMF161 have been requested by and distributed to 1 investigator. |
Contact e-Mail Address |
nmf-mice@jax.org |