Family Identifier |
NMF247 |
Synonym(s) |
C57BL/6J-nmf247/J; JR#5096 |
Synopsis |
Retinal spots, vitreal fibroplasia. |
Gene Symbol |
nmf247 (View MGI Record) |
Gene |
neuroscience mutagenesis facility247 |
Allele Symbol |
nmf247 (View MGI Record) |
Allele |
neuroscience mutagenesis facility247 |
Abnormal Assay(s) |
Assay: Indirect ophthalmoscopy
Domain(s): Eye/Vision
|
Phenotype Description |
Routine ophthalmoscopic examination at 12 weeks of age showed retinal spots and vitreal fibroplasia in NMF247 mutants. Mutants breed well, and a colony can be maintained through homozygous matings.
|
Pathology Report |
Standard pathology work-up on two mutants (84 or 91 days of age) revealed severe photoreceptor degeneration. |
HERITABILITY AND MAPPING INFORMATION
|
Background Strain |
C57BL/6J |
Heritability Mode |
Recessive |
Heritability Status |
Proven; three homozygote x homozygote matings resulted in 17 affected mice in a total of 17 progeny. |
Chromosome |
14 |
Molecular Interval |
between D14Mit207 and D14 Mit234 |
STATUS INFORMATION
|
Mutant Status |
Cryopreserved Embryos
|
Comments |
(15) NMF247 have been requested by and distributed to 3 investigators.
|
Contact e-Mail Address |
nmf-mice@jax.org |