Family Identifier |
NMF195 |
Synonym(s) |
C57BL/6J-nmf195/J; JR# 5009 |
Synopsis |
Grainy retina. |
Gene Symbol |
nmf195 (View MGI Record) |
Gene |
neuroscience mutagenesis facility195 |
Allele Symbol |
nmf195 (View MGI Record) |
Allele |
neuroscience mutagenesis facility195 |
Abnormal Assay(s) |
Assay: Indirect ophthalmoscopy
Domain(s): Eye/Vision
|
Phenotype Description |
Routine ophthalmoscopic examination at 12 weeks of age revealed a grainy appearance of the retina, suggesting a pigmentation defect. The colony is maintained through normal breeding.
|
Pathology Report |
Standard pathology work-up on two mutants (93 or 347 days of age) revealed no gross abnormalities. Additional pathology is in progress.
|
HERITABILITY AND MAPPING INFORMATION
|
Background Strain |
C57BL/6J |
Heritability Mode |
Recessive |
Heritability Status |
Proven; 1 heterozygote x heterozygote mating resulted in 11 affected mice in a total of 93 progeny; one heterozygote x homozygote mating resulted in 11 affected mice in a total of 33 progeny, indicating reduced penetrance. |
STATUS INFORMATION
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Mutant Status |
Cryopreserved Embryos
|
Comments |
Please note: While this mutation is available, it may not yet be chromosomally mapped - an important part of determining whether it is allelic with a previously characterized mutation. (7) NMF195 have been requested by and distributed to 1 investigator. |
Contact e-Mail Address |
nmf-mice@jax.org |