Family Identifier |
NMF191 |
Synonym(s) |
C57BL/6J-Nmf191/J; JR#5007 |
Synopsis |
Grainy retina. |
Gene Symbol |
Nmf191 (View MGI Record) |
Gene |
Neuroscience mutagenesis facility191 |
Allele Symbol |
Nmf191 (View MGI Record) |
Allele |
Neuroscience mutagenesis facility191 |
Abnormal Assay(s) |
Assay: Indirect ophthalmoscopy
Domain(s): Eye/Vision
|
Phenotype Description |
Routine ophthalmoscopic examination at 12 weeks of age identified a grainy appearance of the retina in NMF191 mutants; electroretinographic recordings were normal (n=7). The mutants breed well, and the colony is maintained through regular breeding.
|
Pathology Report |
Standard pathology work-up on two mutants (92 days of age) revealed no gross morphological abnormalities. |
HERITABILITY AND MAPPING INFORMATION
|
Background Strain |
C57BL/6J |
Heritability Mode |
Dominant |
Heritability Status |
Proven; one mating between a C57BL/6J and a heterozygote NMF191 mouse resulted in 7 affected mice in a total of 15 progeny; 2 heterozygote x heterozygote matings resulted in 7 affected mice in a total of 12 progeny.
|
Chromosome |
4 |
Molecular Interval |
between D4Mit111 and D4Mit327 |
STATUS INFORMATION
|
Mutant Status |
Cryopreserved Embryos
|
Comments |
(10) NMF191 have been requested by and distributed to 2 investigators.
|
Contact e-Mail Address |
nmf-mice@jax.org |