Family Identifier |
NMF166 |
Synonym(s) |
B6;129-nmf166/J; JR#5043 |
Synopsis |
Lens extrusion cataract and deep anterior chamber. |
Gene Symbol |
nmf166 (View MGI Record) |
Gene |
Neuroscience mutagenesis facility166 |
Allele Symbol |
nmf166 (View MGI Record) |
Allele |
Neuroscience mutagenesis facility166 |
Abnormal Assay(s) |
Assay: Slit lamp eye exam
Domain(s): Eye/Vision
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Phenotype Description |
Routine eye examination at 12 weeks of age revealed deep anterior chambers, lens extrusion cataracts, and angle dysgenesis in NMF166 mutants (n=29 eyes examined). Male or female mutants have been produced, although so far males have not mated successfully.
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Pathology Report |
Standard pathology work-up on two mutants (84 or 90 days of age) revealed bilateral cataracts and retinal rosettes. Atrophic testes and a lack of sperm (sperm apoptosis in the epididymis) were also noted.
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HERITABILITY AND MAPPING INFORMATION
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Background Strain |
B6;129 |
Heritability Mode |
Recessive |
Heritability Status |
Proven; 4 heterozygote by heterozygote matings produced 20 affected mice in a total of 60 progeny. However, penetrance was low in a mapping cross with CAST (1/34 affected) showing that genetic background is important.
|
Chromosome |
4 |
Molecular Interval |
between D4Mit111(25.1 cM) and D4Mit234 |
STATUS INFORMATION
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Mutant Status |
Cryopreserved Embryos
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Comments |
Please note: 1- While this mutation is available, it has not yet be chromosomally mapped - an important part of determining whether it is allelic with a previously characterized mutation; 2- this mutant mouse line is derived from embryonic stem cells treated with ethylmethanesulfonate (EMS).
(19) NMF166 have been requested by and distributed to 1 investigator. |
Contact e-Mail Address |
nmf-mice@jax.org |