Family Identifier |
NMF131 |
Synonym(s) |
C57BL/6J-nmf131/J; JR#5006 |
Synopsis |
Hyaloid remnants and vitreal fibroplasia with white retinal spots. |
Gene Symbol |
nmf131 (View MGI Record) |
Gene |
neuroscience mutagenesis facility131 |
Allele Symbol |
nmf131 (View MGI Record) |
Allele |
neuroscience mutagenesis facility131 |
Abnormal Assay(s) |
Assay: Indirect ophthalmoscopy
Domain(s): Eye/Vision
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Phenotype Description |
Routine ophthalmoscopic examination showed hyaloid remnants and vitreal fibroplasia with white retinal spots in the majority of mutants, and cataracts, corneal scarring, microphthalmia, and/or cataracts in some mutants. The colony can be maintained through regular breeding; however, because of the low penetrance of the phenotype, which requires a large number of animals to be tested, and our limited testing capacity, we chose to cryopreserve the line. NMF131 is not available live; if you are interested in these mutants please inquire about details of availability.
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Pathology Report |
Standard pathology work-up on 3 mutants (100, 116 or 173 days of age) showed variable retinal and vitreal abnormalities which include retinal dysplasia, topical degeneration and vitreal fibroplasia. |
HERITABILITY AND MAPPING INFORMATION
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Background Strain |
C57BL/6J |
Heritability Mode |
Recessive |
Heritability Status |
Proven; 2 heterozygote x heterozygote matings resulted in 4 affected mice in a total of 29 progeny.
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STATUS INFORMATION
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Mutant Status |
Cryopreserved Embryos
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Comments |
Please note: 1- While this mutation is available, it has not been chromosomally mapped - an important part of determining whether it is allelic with a previously characterized mutation. 2- The majority of frozen NMF embryos is obtained through matings between homozygous (or heterozygous) mutant males and wild-type females; if recovery of mutants is requested, the mice will be shipped as soon as possible following wean without further phenotype or genotype testing. NMF embryos are supplied subject to the General Terms and Conditions of Sale posted at www.jaxmice.jax.org. For prices or further information, please inquire at srp@jax.org or nmf-mice@jax.org. |
Contact e-Mail Address |
nmf-mice@jax.org |