Family Identifier |
NMF192 |
Synonym(s) |
C57BL/6J-nmf192/J; JR#5008 |
Synopsis |
Retinal spots, mottled retinae. |
Gene Symbol |
nmf192 (View MGI Record) |
Gene |
neuroscience mutagenesis facility192 |
Allele Symbol |
nmf192 (View MGI Record) |
Allele |
neuroscience mutagenesis facility192 |
Abnormal Assay(s) |
Assay: Indirect ophthalmoscopy
Domain(s): Eye/Vision
Assay: Eye histology
Domain(s): Eye/Vision
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Phenotype Description |
Routine ophthalmoscopic examination revealed mutants with retinal spots or mottled retinae. Because the phenotype shows similarities to the rd1 phenotype, allele testing with rd1 is in progress. Male mutants do not breed well, and the colony is maintained through heterozygote matings.
|
Pathology Report |
Histology performed on a single eye surgically removed from a mutant at 186 days of age, revealed severe photoreceptor degeneration. Additional pathology is in progress. |
HERITABILITY AND MAPPING INFORMATION
|
Background Strain |
C57BL/6J |
Heritability Mode |
Recessive |
Heritability Status |
Proven; 2 heterozygote matings produced 3 affected mice in a total of 11 progeny. |
STATUS INFORMATION
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Mutant Status |
Cryopreserved Embryos
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Comments |
Please note:1- While this mutation is available, it has not yet been chromosomally mapped - an important part of determining whether it is allelic with a previously characterized mutation; 2- The majority of frozen NMF embryos is obtained through matings between homozygous (or heterozygous) mutant males and wild-type females; if recovery of mutants is requested, the mice will be shipped as soon as possible following wean without further phenotype or genotype testing. NMF embryos are supplied subject to the General Terms and Conditions of Sale posted at www.jaxmice.jax.org. For prices or further information, please inquire at srp@jax.org or nmf-mice@jax.org; 3- (44) NMF192 have been requested by and distributed to 4 investigators.
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Contact e-Mail Address |
nmf-mice@jax.org |