STRAIN INFORMATION
Family Identifier
 NMF219
Synonym(s)
 C57BL/6J-nmf219/J; JR#4831
Synopsis
 Circling and head tossing behavior observed by weaning age; mutants are deaf.
Gene Symbol
 nmf219 (View MGI Record)
Gene
 neuroscience mutagenesis facility219
Allele Symbol
 nmf219 (View MGI Record)
Allele
 neuroscience mutagenesis facility219
Abnormal Assay(s)
 Assay: Auditory brain stem response (ABR)

   Domain(s): Auditory/Vestibular

Assay: Overt movement/posture

   Domain(s): Visible Mutants
Phenotype Description
 The mutants exhibit circling and head tossing behavior by weaning age (average date of onset 3.7 weeks of age +/- 0.66; n=20), and two animals tested for Auditory brainstem response at 6 weeks of age were found to be deaf. Male or female mutants have been produced and a colony can be maintained through heterozygote or mutant breeding (though heterozygotes breed better than mutants).   (View video)
Pathology Report
 Standard pathology work-up on four mutants (29, 36 or 111 days of age) revealed abnormal development of the ears of three mutants. Serial sections of the ears of a 29 and a 111 day old mutant showed a lack of organization, no properly formed hair cells were observed in the older mouse; the semicircular canals also appeared very small. However, whole ear histology performed on an additional mutant (29 days of age) revealed no abnormalities. In the 36 day old mutant, macrophages were present in spinal and trigeminal nerve roots, as well as in the white matter of the CNS. No other abnormalities were observed.
HERITABILITY AND MAPPING INFORMATION
Background Strain
 C57BL/6J
Heritability Mode
 Recessive
Heritability Status
 Proven; 2 heterozygote matings produced 4 affected mice in a total of 11 progeny.
Chromosome
 16
Molecular Interval
 D16Mit34 - 1.9 cM - nmf219 - 7.6 cM - D16Mit58; Linkage D16Mit134 - LOD = 9.0; D16Mit58 - LOD = 6.2
Map
STATUS INFORMATION
Mutant Status
 Cryopreserved Embryos
Comments
 (2) NMF219 have been requested by and distributed to 1 investigator.
Contact e-Mail Address
 nmf-mice@jax.org