STRAIN INFORMATION
Family Identifier
 NMF172
Synonym(s)
 C57BL/6J-nmf172/J; JR#4818
Synopsis
 Circling (bi-directional), head tossing behavior observed by weaning age; the mutants are deaf.
Gene Symbol
 nmf172 (View MGI Record)
Gene
 neuroscience mutagenesis facility172
Allele Symbol
 nmf172 (View MGI Record)
Allele
 neuroscience mutagenesis facility172
Abnormal Assay(s)
 Assay: Auditory brain stem response (ABR)

   Domain(s): Auditory/Vestibular

Assay: Overt movement/posture

   Domain(s): Visible Mutants
Phenotype Description
 The mutants exhibit (bi-directional) circling and head tossing behavior by 4 weeks of age, and of 3 mutants tested for Auditory brainstem responses (at 6 weeks of age) 2 were found to be deaf and 1 hearing impaired. Male or female mutants have been produced and the colony can be maintained through heterozygote or mutant breeding (although heterozygotes breed better than mutants).   (View video)
Pathology Report
 Standard pathology work-up on two mutants (95 or 173 days of age), including serial sections of the ears of one animal (95 days of age) showed no abnormalities. Whole ear exam performed on a third mutant (47 days of age) also showed no abnormalities.
HERITABILITY AND MAPPING INFORMATION
Background Strain
 C57BL/6J
Heritability Mode
 Recessive
Heritability Status
 Proven; 3 heterozygote matings produced 6 affected mice in a total of 19 progeny.
Chromosome
 10
Molecular Interval
 D10Mit138 - 5.5 cM - nmf172 - 4.4 cM - D10Mit15; Linkage D10Mit138 - LOD=8.5; D10Mit15 - LOD=10.5
Map
STATUS INFORMATION
Mutant Status
 Cryopreserved Embryos
Comments
 Please note: The majority of frozen NMF embryos is obtained through matings between homozygous (or heterozygous) mutant males and wild-type females; if recovery of mutants is requested, the mice will be shipped as soon as possible following wean without further phenotype or genotype testing. NMF embryos are supplied subject to the General Terms and Conditions of Sale posted at www.jaxmice.jax.org. For prices or further information, please inquire at srp@jax.org or nmf-mice@jax.org.
Contact e-Mail Address
 nmf-mice@jax.org