Family Identifier |
NMF206 |
Synonym(s) |
C57BL/6J-nmf206/J; JR#4830 |
Synopsis |
The mutants develop a body tremor by weaning age. |
Gene Symbol |
nmf206 (View MGI Record) |
Gene |
neuroscience mutagenesis facility206 |
Allele Symbol |
nmf206 (View MGI Record) |
Allele |
neuroscience mutagenesis facility206 |
Abnormal Assay(s) |
Assay: Overt movement/posture
Domain(s): Visible Mutants
; Movement/Neuromuscular Function
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Phenotype Description |
These mutants have splayed hind limbs and develop a body tremor by weaning age (mean 4.4 weeks of age +/-0.48; n=17). Mutants of either sex have been observed and the colony is obtained through homozygous matings.
(View video)
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Pathology Report |
Standard pathology work-up on one mutant (77 days of age) revealed severe mononuclear lymphocytic nephritis; lymphocytes were also noted in the lung. |
HERITABILITY AND MAPPING INFORMATION
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Background Strain |
C57BL/6J |
Heritability Mode |
Recessive |
Heritability Status |
Proven; 3 heterozygote matings produced 5 affected mice in a total of 13 progeny; 1 mutant x heterozygote mating produced 4 affected mice in a total of 9 progeny. |
Chromosome |
7 |
Molecular Interval |
(D7Mit178, nmf206) - 11.0 cM - D7Mit246 - 15.5 cM - D7Mit82; Linkage D7Mit178 LOD = 12.7 |
Map
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STATUS INFORMATION
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Mutant Status |
Cryopreserved Embryos
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Comments |
Please note: The majority of frozen NMF embryos is obtained through matings between homozygous (or heterozygous) mutant males and wild-type females; if recovery of mutants is requested, the mice will be shipped as soon as possible following wean without further phenotype or genotype testing. NMF embryos are supplied subject to the General Terms and Conditions of Sale posted at www.jaxmice.jax.org. For prices or further information, please inquire at srp@jax.org or nmf-mice@jax.org.
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Contact e-Mail Address |
nmf-mice@jax.org |