Family Identifier |
NMF128 |
Synonym(s) |
C57BL/6J-Nmf128/J; JR#4851 |
Synopsis |
The mutants show spots on retina and in vitreous body. |
Gene Symbol |
Nmf128 (View MGI Record) |
Gene |
Neuroscience mutagenesis facility128 |
Allele Symbol |
Nmf128 (View MGI Record) |
Allele |
Neuroscience mutagenesis facility128 |
Abnormal Assay(s) |
Assay: Indirect ophthalmoscopy
Domain(s): Eye/Vision
Assay: Slit lamp eye exam
Domain(s): Eye/Vision
Assay: Eye histology
Domain(s): Eye/Vision
|
Phenotype Description |
Routine ophthalmoscopic examination at 8 weeks of age revealed unusual spots on the retina and in the vitreous body, in addition to scarring and scleralization of the cornea. The colony is maintained through normal breeding.
|
Pathology Report |
Standard pathology work-up on one mutant (122 days of age) showed a cataract and dysplastic retina with folds in one eye; the other eye appeared normal. There was also a mineral deposit in the wall of the middle ear. |
HERITABILITY AND MAPPING INFORMATION
|
Background Strain |
C57BL/6J |
Heritability Mode |
Dominant |
Heritability Status |
Proven; 2 matings between affected mice produced 11 affected mice in a total of 13 progeny; 1 mating between an affected and a wild-type mouse produced 4 affected mice in a total of 7 progeny. |
STATUS INFORMATION
|
Mutant Status |
Cryopreserved Embryos
|
Comments |
Please note: 1- While this mutation is available, it has not yet been chromosomally mapped - an important part of determining whether it is allelic with a previously characterized mutation; 2- The majority of frozen NMF embryos is obtained through matings between homozygous (or heterozygous) mutant males and wild-type females; if recovery of mutants is requested, the mice will be shipped as soon as possible following wean without further phenotype or genotype testing. NMF embryos are supplied subject to the General Terms and Conditions of Sale posted at www.jaxmice.jax.org. For prices or further information, please inquire at srp@jax.org or nmf-mice@jax.org.
(12) NMF128 have been requested by and distributed to 2 investigators. |
Contact e-Mail Address |
nmf-mice@jax.org |