STRAIN INFORMATION |
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Family Identifier |
NMF127 | |
Synonym(s) |
C57BL/6J-nmf127/J; JR#4814 | |
Synopsis |
The mutants are small and ataxic. | |
Gene Symbol |
nmf127 (View MGI Record) | |
Gene |
neuroscience mutagenesis facility127 | |
Allele Symbol |
nmf127 (View MGI Record) | |
Allele |
neuroscience mutagenesis facility127 | |
Abnormal Assay(s) |
Assay: Overt movement/posture Domain(s): Visible Mutants ; Movement/Neuromuscular Function Assay: Body weight Domain(s): Growth/Development |
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Phenotype Description |
The mutants show exaggerated hind limb movements and intense trunk swaying without much body tremor, which can be observed by weaning age (average on-set 3.5 +/- 0.7 weeks of age). Male or female mutants have been produced, though a colony needs to be maintained through ovarian transplants. | |
Pathology Report |
Standard pathology work-up on two mutants (31 or 32 days of age) showed general wasting and an atrophic thymus with apoptosis. | |
| HERITABILITY AND MAPPING INFORMATION |
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Background Strain |
C57BL/6J | |
Heritability Mode |
Recessive | |
Heritability Status |
Proven; 3 heterozygote matings produced 5 affected mice in a total of 21 progeny. | |
Chromosome |
10 | |
Molecular Interval |
D10Mit66 - 4.6 cM - (nmf127, D10Mit246) - 6.3 cM - D10Mit214; linkage D10Mit246 LOD= 10.3; D10Mit166 LOD = 6.0 | |
Map |
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| STATUS INFORMATION |
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Mutant Status |
Cryopreserved Embryos | |
Comments |
Please note: The majority of frozen NMF embryos is obtained through matings between homozygous (or heterozygous) mutant males and wild-type females; if recovery of mutants is requested, the mice will be shipped as soon as possible following wean without further phenotype or genotype testing. NMF embryos are supplied subject to the General Terms and Conditions of Sale posted at www.jaxmice.jax.org. For prices or further information, please inquire at srp@jax.org or nmf-mice@jax.org. (10) NMF127 have been requested by and distributed to 1 investigator. | |
Contact e-Mail Address |
nmf-mice@jax.org | |