Family Identifier |
NMF220 |
Synonym(s) |
C57BL/6J-nmf220/J; JR#4832 |
Synopsis |
Intense body tremor (at rest and during movement) observed by weaning age. |
Gene Symbol |
Nmf220 (View MGI Record) |
Gene |
Neuroscience mutagenesis facility220 |
Allele Symbol |
Nmf220 (View MGI Record) |
Allele |
Neuroscience mutagenesis facility220 |
Abnormal Assay(s) |
Assay: Overt movement/posture
Domain(s): Visible Mutants
; Movement/Neuromuscular Function
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Phenotype Description |
The mutants exhibit an intense body tremor observed during movement and rest by 4 weeks of age (mean 4.3+/-0.48 weeks; n=21). Mutants of either sex have been produced, and the colony is maintained through regular breeding.
(View video)
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Pathology Report |
Standard pathology work-up on two mutants (30 days of age) revealed no abnormalities. |
HERITABILITY AND MAPPING INFORMATION
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Background Strain |
C57BL/6J |
Heritability Mode |
Dominant |
Heritability Status |
Proven; 1 C57BL/6J x mutant mating produced 11 affected mice in a total of 21 progeny. |
Chromosome |
2 |
Molecular Interval |
D2Mit94 - 8.5 cM - Nmf220 - 5.9 cM - D2Mit447; D2Mit94 LOD = 6.4; D2Mit447 LOD = 5.5 |
Map
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STATUS INFORMATION
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Mutant Status |
Cryopreserved Embryos
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Comments |
Please note: 1-While this mutation is available, it has not yet been chromosomally mapped - an important part of determining whether it is allelic with a previously characterized mutation; 2- The majority of frozen NMF embryos is obtained through matings between homozygous (or heterozygous) mutant males and wild-type females; if recovery of mutants is requested, the mice will be shipped as soon as possible following wean without further phenotype or genotype testing. NMF embryos are supplied subject to the General Terms and Conditions of Sale posted at www.jaxmice.jax.org. For prices or further information, please inquire at srp@jax.org or nmf-mice@jax.org.
(7) NMF220 have been requested by and distributed to 2 investigators.
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Contact e-Mail Address |
nmf-mice@jax.org |