STRAIN INFORMATION
Family Identifier
 NMF111
Synonym(s)
 C57BL/6J-nmf111/J; JR#4812
Synopsis
 The mutants are small and show a subtle body tremor; thinning of peripheral retina.
Gene Symbol
 nmf111 (View MGI Record)
Gene
 neuroscience mutagenesis facility111
Allele Symbol
 nmf111 (View MGI Record)
Allele
 neuroscience mutagenesis facility111
Abnormal Assay(s)
 Assay: Overt movement/posture

   Domain(s): Movement/Neuromuscular Function ; Visible Mutants

Assay: Body weight

   Domain(s): Growth/Development

Assay: Eye histology

   Domain(s): Histology
Phenotype Description
 The mutants can easily be identified at wean by their small size and all develop a subtle body tremor that is apparent by 8 weeks of age, but may appear as early as 3-4 weeks (average time of onset 47.2+/-18.2 days); they walk low on their hind limbs, which also show intermittently a prolonged extension, making their movement appear to be 'hesitant'. A colony can be maintained through normal breeding.
Pathology Report
 Standard pathology work-up on two mutants (183 days of age) showed thinning along the periphery of the retina.
HERITABILITY AND MAPPING INFORMATION
Background Strain
 C57BL/6J
Heritability Mode
 Recessive
Heritability Status
 Proven; 5 heterozygote matings produced 9 affected mice in a total of 38 progeny.
Chromosome
 4
Molecular Interval
 D4Mit111 - 9.6 cM - nmf111 - 6.4 cM - D4Mit178 - 2.5 cM - D4Mit80; linkage D4Mit178 - LOD = 8.9; D4Mit111 - LOD = 7.3; D4Mit80 - LOD = 6.9 (see comment below)
Map
STATUS INFORMATION
Mutant Status
 Cryopreserved Embryos
Comments
 Alternative mapping area: D4Mit111 - 5.1 cM - D4Mit178 - 5.3 cM - nmf111 - 8.0 cM - D4Mit80. Because of four apparent phenotypic mis-classifications the locus placement results that were received are slightly ambiguous; thus posted here are what is considered the most likely locus (above under 'Molecular Interval') and a second, (almost) equally likely locus (above); the overall mapping to the region is regarded as very solid. Please note: The majority of frozen NMF embryos is obtained through matings between homozygous (or heterozygous) mutant males and wild-type females; if recovery of mutants is requested, the mice will be shipped as soon as possible following wean without further phenotype or genotype testing. NMF embryos are supplied subject to the General Terms and Conditions of Sale posted at www.jaxmice.jax.org. For prices or further information, please inquire at srp@jax.org or nmf-mice@jax.org. (12) NMF111 have been requested by and distributed to 2 investigators.
Contact e-Mail Address
 nmf-mice@jax.org