Family Identifier |
NMF12 |
Synonym(s) |
C57BL/6J-nmf12/J; JR#4110 |
Synopsis |
Thin retina; white intraretinal patches. |
Gene Symbol |
nmf12 (View MGI Record) |
Gene |
neuroscience mutagenesis facility12 |
Allele Symbol |
nmf12 (View MGI Record) |
Allele |
neuroscience mutagenesis facility12 |
Abnormal Assay(s) |
Assay: Indirect ophthalmoscopy
Domain(s): Eye/Vision
Assay: Eye histology
Domain(s): Eye/Vision
|
Phenotype Description |
Single mutant found at 13 weeks of age with retinal patch in left eye. The original mutant was non-productive and ovarian transplants of mutant ovaries also produced no offspring. However, matings of presumed heterozygotes have produced additional offspring.
|
Pathology Report |
Standard pathology work-up on 3 mutants (266, 325 or 360 days of age) showed thinning of the peripheral retinae in both eyes. One eye also showed a small area in which the outer nuclear layer was very thin. |
HERITABILITY AND MAPPING INFORMATION
|
Background Strain |
C57BL/6J |
Heritability Mode |
Recessive |
Heritability Status |
Proven; 7 heterozygote matings produced 31 affected mice in a total of 142 progeny. |
STATUS INFORMATION
|
Mutant Status |
Cryopreserved Embryos
|
Comments |
Please note: 1-The majority of frozen NMF embryos is obtained through matings between homozygous (or heterozygous) mutant males and wild-type females; if recovery of mutants is requested, the mice will be shipped as soon as possible following wean without further phenotype or genotype testing. NMF embryos are supplied subject to the General Terms and Conditions of Sale posted at www.jaxmice.jax.org. For prices or further information, please inquire at srp@jax.org or nmf-mice@jax.org; 2-This mutation has not yet been chromosomally mapped - an important part of determining whether it is allelic with a previously characterized mutation. (89) NMF12 have been requested by and distributed to 2 investigators.
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Contact e-Mail Address |
nmf-mice@jax.org |